LYMPHANGITE CARCINOMATEUSE PDF

Recurrent small cell lung cancer presenting as bilateral adnexal masses. Lymphangite carcinomateuse — EM consulte Merci pour vos avis. Post Your ideas for ProZ. Review native language verification applications submitted by your peers. Return to KudoZ list. Lung carcinoma metastatic to the ovary: Extragenital cancers are dominated by gastro-intestinal and breast tumors.

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It can also be seen in numerous other primary cancers, e. A helpful mnemonic for lymphangitic carcinomatosis is sometimes used for its common causes. Mechanism Spread into the lymphatics in most cases except in bronchogenic adenocarcinoma usually occurs following haematogenous seeding of the lungs, with subsequent lymphatic involvement 1,3.

It may also occur by retrograde spread into the lymphatics from the mediastinal and hilar lymph nodes. Both the peripheral lymphatics coursing in the interlobular septa and beneath the pleura, and the central lymphatics coursing in the bronchovascular interstitium are involved 2.

Histologically tumor is seen both within lymphatics and in the adjacent interstitium, with associated edema and desmoplasia 3,4. Radiographic features Radiographic appearances can most easily be divided into those due to the involvement of the peripheral interlobular septa and central lymphatic system. Involvement may be diffusely of both, or predominantly of one compartment or the other 4. Distribution of changes is variable, but most are asymmetric and patchy 3.

It is usually bilateral but may be unilateral, especially in cases of lung and breast cancer. Plain radiograph Unfortunately up to a quarter of patients with subsequently established lymphangitic carcinomatosis have normal chest x-rays 2. Typically the appearance is that of interlobular septal thickening , most often nodular and irregular, although smooth thickening may also sometimes be seen This results in a prominent definition of the secondary pulmonary lobules, manifesting as tessellating polygons.

There could also be an alveolar filling pattern blending into more reticulation 5. Thickening of the bronchovascular interstitium is usually irregular and nodular, with changes seen extending towards the hilum 4. The combination may give a characteristic " dot in box " appearance. In most cases, lymphangitic carcinomatosis progresses rapidly and patients deteriorate see treatment and prognosis below , however in some cases changes may remain stable over considerable time 3.

Prognosis of patients with lymphangitic carcinomatosis is poor, with approximately half of patients succumbing to their illness within a year of diagnosis 2,3. Differential diagnosis.

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From This Paper Figures, tables, and topics from this paper. A Multicenter European Case-control Study. Citations Publications citing this paper. LymphangietJaymin Bhagwanji Morjaria Therapeutic advances in respiratory disease La nocardiose, une maladie en expansion [Nocardiosis, an expanding disease. Top of the page — Article Outline.

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