This text is suitable for researchers and statisticians working in the medical and other life sciences as well as statisticians in academia who teach introductory and second-level courses on survival analysis. Kleinbaum is internationally known for innovative textbooks and teaching on epidemiological methods, multiple linear regression, logistic regression, and survival analysis. He has provided extensive worldwide short-course training in over short courses on statistical and epidemiological methods. He is also the author of ActivEpi , an interactive computer-based instructional text on fundamentals of epidemiology, which has been used in a variety of educational environments including distance learning.
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This format allows you to read the script in conjunction with the illustrations and formulae that high- light the main points, formulae, or examples being presented. The new chapter is Chapter 10, Design Issues for Randomized Trials, which considers how to compute sample size when designing a randomized trial involving time-to-event data.
We have expanded Chapter 1 to clarify the distinction between random, independent and non-informative censoring assumptions often made about survival data. We also added a section in Chapter 1 that introduces the Counting Process data layout that is discussed in later chapters 3, 6, and 8.
We added sections in Chapter 2 to describe how to obtain confidence intervals for the Kaplan-Meier KM curve and the median survival time obtained from a KM curve. We have expanded Chapter 3 on the Cox Proportional Hazards PH Model by describing the use of age as the time scale instead of time-on-follow-up as the outcome variable.
We also added a section that clarifies how to obtain confidence intervals for PH models that contain product terms that reflect effect modification of exposure variables of interest. We expanded this Appendix to include the free internet-based computer software package call R.
The application of these computer packages to survival data is described in separate self-contained sections of the Computer Appendix, with the analysis of the same datasets illustrated in each section. In addition to the above new material, the original nine chapters have been modified slightly to correct for errata in the second edition and to add or modify exercises provided at the end of some chapters.
Survival Analysis: A Self-Learning Text, Third Edition